I don't remember this being particularly hard but then I've run into the odd "OS X sticks site-packages here" problem before.

"Mac OS X 10.5 ("Leopard") includes libxml2 2.6.16 and libxslt 1.1.12. Some programs require newer versions, such as PostgreSQL, which requires libxml2 2.6.23 or later. This procedure describes how to add a newer version of these libraries to your system without disturbing the preinstalled versions already present. This allows you to use the newer versions as needed while allowing other software to continue using the older versions as intended. I wrote these instructions as I added libxml2 2.6.30 and libxslt 1.1.22 to my system."

"Take care of the little jobs with Organized, a new widget from iSlayer featuring a calendar with events, world clocks, notes and to do's. "

Allows basic cvs style operations on Time Machine volumes

another "php5+mysql on leopard" how to

Similar to Prism from Mozilla but it uses WebKit instead.

CPAN is confused by the Core 2 Duo (and similar) line of chips that are 64 bit (but have 32 bit support...)

"Anxiety is a super-lightweight To-do list application for Mac OS X Leopard that synchronizes with iCal and Mail."

Leopard disables CUPS shared printer discovery by default. WHY?