HTML5 Boilerplate is the professional badass's base HTML/CSS/JS template for a fast, robust and future-proof site.

After more than three years in iterative development, you get the best of the best practices baked in: cross-browser normalization, performance optimizations, even optional features like cross-domain Ajax and Flash. A starter apache .htaccess config file hooks you the eff up with caching rules and preps your site to serve HTML5 video, use @font-face, and get your gzip zipple on.

Boilerplate is not a framework, nor does it prescribe any philosophy of development, it's just got some tricks to get your project off the ground quickly and right-footed.

Blueprint is a CSS framework, which aims to cut down on your CSS development time. It gives you a solid CSS foundation to build your project on top of, with an easy-to-use grid, sensible typography, and even a stylesheet for printing.