arthegall + science   406

"Require free access over the Internet to scientific journal articles arising from taxpayer-funded research." (Petitions | The White House)
Sign it. Then pass it along to your friends to sign. Seriously. (This is a petition, created by John Wilbanks, formerly of Creative Commons, and all-around dynamo or pro-open-access energy.)
open-access  john-wilbanks  creative-commons  science  publishing 
6 days ago by arthegall
Language Log » Bible Science stories, revisited
Liberman debunks the "10% of financial workers on Wall St. are psychopaths" meme. But I *want* to believe!
psychopathy  psychology  science  journalism  mark-liberman  debunking 
13 days ago by arthegall
"DHFR Inhibitors Revisited: A Word From the Authors (and Reviewers)" (In the Pipeline)
A useful antidote (or merely counterpoint?) to the whole Graeber-related nastiness on Crooked Timber a while ago. Similar kind of situation, similar Niceness Police (as Kotsko would put it) showing up in the comments, but still a much more constructive outcome. Eager to read the final follow-up post. [Update-- here: http://pipeline.corante.com/archives/2012/04/26/different_worlds_a_last_dhfr_paper_thought.php ] Seriously, guys, this is what the future of scientific publishing and peer review looks like.
trolls  david-graeber  science  peer-review  drug-discovery  chemistry  biology  blogging 
4 weeks ago by arthegall
The Neutral Model of Inquiry (or, What Is the Scientific Literature, Chopped Liver?)
Writing a version of the thought experiment in this post as a simulation was part of my "fun work" this weekend...
science  statistics  simulation  by:cshalizi  projects  weekend-programming 
4 weeks ago by arthegall
SRA format - SEQanswers
"Guys from NCBI said me that they don't give this documentation anybody. And if you want to use the SRA format then you need to use their API." -- Eeeesh, really?? That's pretty terrible.
public-domain  science  open-access  open-source  sra  genomics  ridiculous 
february 2012 by arthegall
Notebook S1: Scientific publishing awesomeness
"What is amazing is that – as far as I know – this is the first time anyone’s actually done it. And (members of my lab take note) this will not be the last." -- I can almost hear Eisen's students screaming from here. Hilarious!
michael-eisen  science  scanning  lab-notebooks  awesome 
september 2011 by arthegall
ISA
"Investigation, Study, Assay" infrastructure -- to see how this interacts with ontologies like OBI?
annotation  data  ontology  research  science 
august 2011 by arthegall
Re: Schema.org in RDF ... from Richard Cyganiak on 2011-06-11 (public-lod@w3.org from June 2011)
This is intensely depressing, for many reasons. Among other reasons, it means the whole "Google-style Science" project, so touted by people like Chris Anderson, is totally a lost cause. I mean, seriously, good luck with that if you can't distinguish <http://www.ncbi.nlm.nih.gov/gene/25> the Entrez gene data record from <http://www.ncbi.nlm.nih.gov/gene/25> the gene (or any one of a dozen different kinds of things it could reasonably refer to). Sigh.
httprange-14  cygri  alan  via:jenit  schemadotorg  ontology  puns  science  google  data  idiocy 
june 2011 by arthegall
Hopkins, Groom, "The druggable genome" : Article : Nature Reviews Drug Discovery
(doi:10.1038/nrd892) People keep talking about this paper at work -- and Hopkins gave one of the plenaries at IDD this year. I think what this is, is just mapping a lot of the intermediate data that's useful for drug discovery down on to the "genomic coordinate system," and making it available in one location for browsing. Not sure how useful that really is; does it omit something key?
research-article  drug-discovery  genomics  science  annotation  nature  review 
may 2011 by arthegall
The Initiative | ORCID
Ontology for investigators? A replacement for ILAR? Maybe?
ilar  ontology  data  investigators  authors  science  research 
april 2011 by arthegall
Groth, Gibson, and Velterop, "The Anatomy of a Nanopublication"
This is basically SWAN, but five years after the fact -- but drives home the point of how much fo a missed opportunity SWAN really was.
swan  publishing  rdf  semanticweb  science  nanopublications  research-article 
january 2011 by arthegall
Dryad data file: Dryad Home
"Dryad is an international repository of data underlying peer-reviewed articles in the basic and applied biosciences. Dryad enables scientists to validate published findings, explore new analysis methodologies, repurpose data for research questions unanticipated by the original authors, and perform synthetic studies." -- Data publishing, hmm.
bioinformatics  data  publishing  via:jonathan-eisen  biology  science 
january 2011 by arthegall
Authorship ethics | Research tips
I've actually asked to have my name taken *off* a paper, after deciding that most of my contributions fell squarely in the second category. I'm hoping that Shaun hasn't held that against me in the long run.
authorship  science  ethics 
january 2011 by arthegall
ExPORTER - NIH RePORTER Database Download >> Homepage
"This site was created to provide raw data for those who would like to conduct detailed analyses of the research projects found in RePORTER or load these records into their own data systems. These data are drawn from multiple sources and are provided to the public in the spirit of transparency even though the data, and any analyses derived from them, cannot be considered an official report of the NIH or any of the other federal agencies whose records can be found in RePORTER."
nih  data  government  funding  grants  database  science 
november 2010 by arthegall
Study ERS000018: Sequence Read Archive : NCBI/NLM/NIH
"Please tell me that this is not the full extent of the metadata that the SRA retains or requires? Isn't there some MGED (oh, sorry, "FGED") equivalent file that they want experimenters to fill out?
ontologies  metadata  sequencing  fged  mged  experimental-design  science  data  ncbi  question 
october 2010 by arthegall
"This is a news website article about a scientific finding" Martin Robbins, guardian.co.uk
"This is a sub-heading that gives the impression I am about to add useful context.

Here I will state that whatever was being researched was first discovered in some year, presenting a vague timeline in a token gesture toward establishing context for the reader.

To pad out this section I will include a variety of inane facts about the subject of the research that I gathered by Googling the topic and reading the Wikipedia article that appeared as the first link."
humor  science  journalism  journamalism  yakawow 
september 2010 by arthegall
AmeriFlux
"The AmeriFlux network was established in 1996. The network provides continuous observations of ecosystem level exchanges of CO2, water, energy and momentum spanning diurnal, synoptic, seasonal, and interannual time scales and is currently composed of sites from North America, Central America, and South America."
via:johnwilbanks  data  public  climate  science 
september 2010 by arthegall
"Data Sharing News: NSF Links to Open Context and tDAR" (Digging Digitally)
"Now for some context: Earlier this year, the NSF announced new data sharing requirements for grantees. Grant-seekers now need to supply data access and management plans in their proposals. This new requirement has the potential for improving transparency in research. Shared data also opens the door to new research programs that bring together results from multiple projects. ...
That’s why it is useful for the NSF to link to specific systems and services. Along with Open Context, the NSF also links to Digital Antiquity’s tDAR system (Kudos to Digital Antiquity!). Open Context offers researchers guidance on how prepare datasets for presentation and how to budget for data dissemination and archiving (with the California Digital Library). Open Context also points to the “Good Practice” guides prepared by the Archaeology Data Service (and being revised with Digital Antiquity). Researchers can incorporate all of this information into their grant applications."
nsf  science  data-sharing  data  archive  open-context  tdar  data-publishing 
september 2010 by arthegall
iPhylo: Viewing scientific articles on the iPad: towards a universal article reader
The first in a series of posts from Rod Page, about reading scientific articles on smaller devices (iPads, other tablets) -- he's reviewing the presentation, interaction, UI, and visual tropes of a couple different readers, in preparation for talking about building an app to read phylogenetics papers on the same platforms. These are worth bookmarking and reading -- they're probably useful for thinking about how to read other media as well (magazines? newspapers? something else?). I've been intending to forward this to Sam when I get a chance...
by:rod-page  science  publishing  ipad  ui  design  web  tablet-devices  plos  phylogenetics 
september 2010 by arthegall
Complexity and Social Networks Blog: The end of Supporting Material?
A datapoint for JAR. (For the record, I think that reviewing practices are *broken*, at least in the sub-areas of CS where I've been able to see behind the curtain, but I also think that nixing "supplementary information" is a step in the wrong direction. The right move here would be to think more carefully about how to make it easier for people to review the material, not how to reduce the amount of material overall...)
data  publishing  journals  science  peer-review  supplementary-information 
september 2010 by arthegall
"Independent Introduction of Two Lactase-Persistence Alleles into Human Populations Reflects Different History of Adaptation to Milk Culture"
Normally, lactase persistence ("LP") is associated with a particular SNP in an enhancer 13kb upstream of the lactase (LCT) gene. Here they show, though, that (as you might expect) there are other variants in different human subpopulations which give rise to the same phenotype. (I think this is the Broad's "ability to drink milk arose twice in human evolution" paper that I remember seeing touted on their Main St. display screens a year or two ago.)
milk  lactase  science  genomics  evolution  transcriptional-regulation  research-article 
august 2010 by arthegall
2010 Gruber Genetics Prize
This year's winner: Gerry Fink. "For the development of yeast transformation." Accolades, plus a small honorarium for speaking at their awards' ceremony in December. Nice!
via:arolfe  genetics  prize  gerry-fink  yeast  yeast-transformation  science  award 
august 2010 by arthegall
"SNPwatch: Uncertainty Surrounds Longevity GWAS" (The Spittoon)
The Spittoon (the blog from 23andme) does the follow-up on that fishy-smelling "here are a bunch of genetic variants associated with longevity" study that got all that press a few months ago.
23andme  spittoon  review  longevity  gwas  statistics  uncertainty  genomics  genetics  science  news 
august 2010 by arthegall
Kennefick, "Not Only Because of Theory: Dyson, Eddington and the Competing Myths of the 1919 Eclipse Expedition" (arXiv)
Rudolf Moritz writing to Phillip Cowell, in 1918: "I can well understand the compatriots of Riemann and Christoffel burning Louvain and sinking the Lusitania. In other words, the atrocity of inventing the tensor-based mechanisms of differential geometry which underpin general relativity is quite on a par, morally speaking, with the most notorious (to Englishmen) war crimes of World War I."
eddington  einstein  measurement  history  science  quote  arxiv  astronomy  relativity  physics 
july 2010 by arthegall
"Open-Source Pharmaceutical Babble" (In the Pipeline)
"And that's it; that's the payoff. We'll all just hop to it, enabling and facilitating, expanding and evolving, stimulating and focusing. None of those are concrete verbs suggesting real courses of action. Whenever you see someone slip into that sort of talk, you can be sure that (at the very least) they have difficulty communicating whatever specific ideas they have. Or (more likely) that they don't have any specific ideas to tell you about at all."
opensource  buzzwords  pharmaceuticals  research  community  web  futurism  science 
july 2010 by arthegall
PHYLO: THE TRADING CARD GAME
For thinking about publishing gameplay online...
phylo  game  card-game  science  education  taxonomy 
july 2010 by arthegall
"Sergey Brin’s Search for a Parkinson’s Cure" (Wired)
"Grove disagrees somewhat with Brin’s emphasis on patterns over hypothesis. “You have to be looking for something,” he says. But the two compare notes on the disease from time to time; both are enthusiastic and active investors in the Michael J. Fox Foundation. (Grove is even known to show up on the online discussion forums.)" --- Hmm. ("All Wired articles are wrong, and increasingly...." etc etc).
wired  sergey-brin  michael-j-fox-foundation  parkinsons  health  medicine  science  big-data  obscurely-referential 
june 2010 by arthegall
New Scientist - 5th March 1987 "The race to map the human genome"
Picked up by Shaun...
Robert Weinberg (MIT): "I'm surprised consenting adults have been caught talking about it [sequencing the genome]... it makes no sense."
David Botstein (MIT): "I do not believe that there is any strong scientific justification for knowing the sequence of the entire human genome".

So, Shaun, do you think they (Botstein and Weinberg) have been proven right or wrong?
via:WanderingAengus  david-botstein  robert-weinberg  quotes  human-genome  genomics  futurism  science  biology 
june 2010 by arthegall
That Which Does Not Kill Me Makes Me Stranger - New York Times
"‘During race, I am going crazy, definitely,’’ he says, smiling in bemused despair. ‘‘I cannot explain why is that, but it is true.’’"
sports  biking  nytimes  science  health  psychology  insanity 
june 2010 by arthegall
Airport security: Intent to deceive? : Nature News
Wait, wait wait wait.... are you trying to tell me that a "deception spotting" technique used by the TSA, and based on "scientific" work which turns out to be mostly a couple of Malcolm Gladwell articles and a season-and-a-half of a Fox primetime drama, is really just snakeoil-derived security-theater? I'm stunned, you could knock me over with a feather.
security-theater  tsa  malcolm-gladwell  science  idiocy 
june 2010 by arthegall
Findings - Daring to Discuss Women’s Potential in Science - NYTimes.com
"Of course, a high score on a test is hardly the only factor important for a successful career in science, and no one claims that the right-tail disparity is the sole reason for the relatively low number of female professors in math-oriented sciences." -- Then Tierney performs the "two-step of terrific triviality!" Buried on page two, no less. Nice.
two-step  john-tierney  science  education  culture  larry-summers  idiocy 
june 2010 by arthegall
DNA Precipitation - OpenWetWare
An open question: how could you re-code these kinds of protocol descriptions in OBI? What kinds of authoring tools would you need? How would you want to display the information when you were done? (ALSO: "source code"? Whoaaa.....)
obi  protocol  science  data  wiki  openwetware  ontology  logic  description  formal-methods 
may 2010 by arthegall
Sustainability of Human Progress
"It is still controversial whether global warming from CO2 is occurring or whether recent warm years are a statistical fluctuation or a consequence of changes in the sun." -- I didn't realize that John McCarthy (of LISP fame) was a climate-change skeptic. Fascinating. Sort of.
climate-change  john-mccarthy  skepticism  science  technology  environment  via:arsyed 
may 2010 by arthegall
Synthetic Bacterial Genome Takes Over Cell - NYTimes.com
Amazingly, Nicholas Wade appears to have gotten cautious or negative comments from David Baltimore, George Church, *and* Leroy Hood -- a trifecta, of sorts.
nicholas-wade  nytimes  science  journalism  george-church  craig-venter  synthetic-biology  biology  news  genomics 
may 2010 by arthegall
ScienceCheck
"ScienceCheck.org is the only site dedicated specifically to sharing objective evaluations of published experimental methods/protocols, from researchers with real-world experience." -- I'm not sure I'd say *only*, but it looks like a reasonable example of the interface.
science  collaboration  protocols  experiments  web  evaluation 
may 2010 by arthegall
10 Open Source Projects Changing Medicine — Syslab.com GmbH
Aside from PLoS and i2b2, I'm not sure how many of these have a realistic chance of success. MedSphere seems like a kind of competitor to SCF. Still, might be worth a look.
collaboration  medicine  science  futurism  list  open-source  biology 
may 2010 by arthegall
iPhylo: Wiki frustration
Rod Page freakin' out about the difficulty of executing joins in Semantic Mediawiki.
semanticweb  semantic-mediawiki  rod-page  phylogenetics  science  impedance-mismatch  wiki 
april 2010 by arthegall
Erika Hayden, "Human genome at ten: Life is complicated" (Nature News)
"In many cases, the models themselves quickly become so complex that they are unlikely to reveal insights about the system, degenerating instead into mazes of interactions that are simply exercises in cataloguing." --- Suck it, Chris Anderson. (More seriously, this is a reasonably good 10,000 ft. overview of the state-of-play in systems biology and genomics, I think.)
nature  science  genomics  big-science  chris-anderson  systems-biology  biology 
march 2010 by arthegall
StemBook Home | StemBook
Alex, I'm working with the people who run this... if you think it's interesting, send me an email.
stem-cells  work  website  science  biology 
march 2010 by arthegall
Carole Goble, "The Seven Deadly Sins of Bioinformatics" (slideshare)
JAR sent me this, and while the slide design isn't good, the message is long and dense and wonderful and funny and exactly right. I will confess to being guilty of at least six of these sins myself.
bioinformatics  humor  culture  science  technology  ontology  slides  presentation  sins  mistakes  semanticweb  data  database  information 
january 2010 by arthegall
"The Unreality of Time" (John Emerson)
Locus classicus for why I find Emerson's writing so useless. (How can you write an entire essay about 'time' without mentioning 'memory' once?)
john-emerson  time  philosophy  science  physics 
january 2010 by arthegall
Wesley C. Salmon - Wikipedia, the free encyclopedia
Probably should have bought and read one of his books (Scientific Explanation and the Causal Structure of the World) a long time ago.
via:cshalizi  causality  science  philosophy  philosophy-of-science  book  recommendation 
january 2010 by arthegall
P³G Observatory - Home
The "observatory" is a (apparently) a set of hand-curated *pairs* of population genomics studies, reviewed to discover whether they are compatible with each other, that is, whether they can be used in the same meta-analysis.
population-genetics  meta-analysis  genomics  data  science  research 
december 2009 by arthegall
Language Log » The business of newspapers is news
"In other words, the more prestigious the journal (as measured by its "impact factor"), the less likely the genetic association studies it publishes are to be replicated." -- a great line. But to be honest, I'm less concerned by this kind of thing today than I was (probably) a year ago. First of all, I expect it from Wade. But second, I don't have that high an opinion of the vetting process that goes into journal articles. Peer review is not the arbiter of truth, it's the beginning of the investigation -- plenty of carefully-worded refereed journal articles (*especially* in Nature & Science) are also over-ambitious, breathlessly phrased, and written to attract (more) funding. Whatever the business of newspapers is, it should be clear that the business of [some] journals is not science, but *surprising* science. That's often a different thing.
publishing  science  culture  newspapers  nyt  nicholas-wade  via:cshalizi 
december 2009 by arthegall
GRO
The central website (apparently) from EBI -- the rebholz lab is doing automatic text annotaiton and extraction of these kinds of events.
science  text-mining  search  gene-regulation  bioinformatics  nlp  ebi 
november 2009 by arthegall
http://galaxy.psu.edu/
A web-based tool for glue-ing together command-line scripts, along with some workflow representations, visualization, and standard toolsets. For bioinformatics. Shaun just demo'ed this for me, and it looks *really good*.
bioinformatics  software  web  tool  workflow  genomics  science 
november 2009 by arthegall
Webb et al. "Widespread Occurrence of Self-Cleaving Ribozymes" Science 326:5955, pg. 953 (2009)
"Hepatitis delta virus (HDV) and cytoplasmic polyadenylation element–binding protein 3 (CPEB3) ribozymes form a family of self-cleaving RNAs characterized by a conserved nested double-pseudoknot and minimal sequence conservation. Secondary structure–based searches were used to identify sequences capable of forming this fold, and their self-cleavage activity was confirmed in vitro. ... Our results indicate that HDV-like ribozymes are abundant in nature and suggest that self-cleaving RNAs may play a variety of biological roles."
research-article  functional-rna  noncoding-rna  science  biology  genomics 
november 2009 by arthegall
Lincoln Stein, "Creating a bioinformatics nation"
A Nature perspectives article, adapted from a keynote at a Tim O'Reilly conference. Data formats, bioinformatics, open access, etc etc. Talked up by JAR.
via:jar  lincoln-stein  nature  science  bioinformatics  data  openaccess  library 
november 2009 by arthegall
"The hunt for the Hat Gene" (Language Log)
I've said it once, I'll say it again -- *You Cannot Trust the NYT Science Writers.* They're not in the business of explaining science; they are in the business of sensationalizing science for the readers who happened to have wandered off of the NYT Fashion section and are wondering where they are.
via:cshalizi  genes  phenotype  science  journamalism 
november 2009 by arthegall
Publications (Bertram Ludäscher)
Dave Thau's advisor -- publications on scientific workflow representation.
workflow  science  publications  researcher  homepage 
november 2009 by arthegall
Open Source Science? Or Distributed Science? : Common Knowledge
"A third problem is that science is a long, long, long, long, long way from being a modular knowledge construction discipline." -- Needs more "longs."
by:johnwilbanks  science  openaccess  web 
november 2009 by arthegall
The Transmissibility and Control of Pandemic Influenza A (H1N1) Virus -- Yang et al. 326 (5953): 729 -- Science
"If a vaccine were available soon enough, vaccination of children, followed by adults, reaching 70% overall coverage, in addition to high-risk and essential workforce groups, could mitigate a severe epidemic." -- Gotta forward this to R.
swine-flu  science  research-article  vaccination  pandemic  medicine 
november 2009 by arthegall
Collins et al. "The Human Genome Project: Lessons from Large-Scale Biology"
A 2003 retrospective on the organization, milestones, and management of large-scale (factory-style) genomics research.
human-genome-project  genomics  management  biology  research  science  factory-science 
november 2009 by arthegall
Cell Size and Scale
Powers of 10, but with genetics and biological items! Very nicely done, and ... actually, quite informative.
yeast  biology  visualization  scale  flash  animation  science  via:jar 
october 2009 by arthegall
Random List of Science Blogs
A quick list, to get these out of my tabs. To send to Gwen and Elizabeth, eventually. (Question: does anyone know a good Alzheimer's researcher who blogs? Finding such a blog would make my life somewhat more interesting...)
alzheimers  list  blogging  science  personal 
october 2009 by arthegall
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