transformation   10461

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The how, the why and, the what of manufacturers moving to the cloud
He also talks about how embracing the cloud enables manufacturers to adopt new business models, such as servitisation, but it is not the best approach for everyone. Dalziel noted that: “it opens the door for digital transformation”. The struggle for many manufacturers still struggling with on-premises software and hardware is that they find it much harder to change."
erp  podcasts  business  cloud  digital  transformation  innovation  manufacturing  on-premises  saas  servitisation  sla 
8 days ago by jonerp
From 30 miles per day to 30 steps
"How will public transportation systems be impacted? Cities, particularly here in the US, have a bigger problem. With the increasing popularity of on-demand mobility services, they saw a significant decrease in public transportation ridership. Social distancing will decrease the passenger density on these systems, but that density is necessary for these systems to meet their financial goals. Cities are constantly disinfecting their buses, trains, subways, and light rail cars, but the public is still worried about getting infected. Longer term, the cities will have to find a way to reassure the public about how clean the public transportation system is and remains. Will the public accept to pay more taxes for transportation that assures less crowded modalities?"
next-generation  mobility  covid-19  goods  delivery  services  pandemic  shelter  in  place  transportation  transformation 
10 days ago by jonerp
A Guide for Designing a Successful Corporate Transformation
Four building blocks
1. Creating a strategic identity
2. Designing for trust
3. Mastering the pivot from sprint to scale
4. Treating your legacy as an asset (capabilties)
transformation  pwc 
14 days ago by tom.reeder
kay_greatness | Okay, so here's my whale story.
Summary: John the Orca decides to follow Rodney his trainer home one day and through magic, he can.
au  shapeshifter  f:sga  p:rodney/john  transformation  au:werecreature/shapeshifter 
23 days ago by miss_speller
L'ABF, l'ADBGV, l'ABD et Bibliopat interpellent le ministre de la Culture - Association des Bibliothécaires de France
Un Plan de transformation ministériel est actuellement en cours au sein du ministère de la Culture. La perspective de création d’une nouvelle direction incluant les bibliothèques peut être une perspective intéressante, si elle permet de valoriser et d’étendre des politiques de lecture publique ambitieuses dans notre pays, dans la continuité du plan bibliothèques que vous conduisez. 

Comme nous l'avions fait dans notre courrier du 22 janvier, nous souhaitons attirer votre attention sur les risques et dangers d’une éventuelle séparation entre le champ du patrimoine écrit d’une part, et les autres missions  des bibliothèques d’autre part. Nous sommes très inquiets d’une telle hypothèse et considérons qu’il est indispensable de maintenir le domaine des bibliothèques au sein d’une même direction incluant lecture publique et patrimoine écrit. Nous y voyons une condition pour maintenir et amplifier des politiques publiques cohérentes pour les bibliothèques. 
bibliothèques  patrimoine  MCC  SLL  transformation  ministère  Riester  ABF 
28 days ago by sentinelle
The tumor suppressor PP2A Aβ regulates the RalA GTPase
The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric enzyme family that regulates numerous signaling pathways. Biallelic mutations of the structural PP2A Aβ subunit occur in several types of human tumors; however, the functional consequences of these cancer-associated PP2A Aβ mutations in cell transformation remain undefined. Here we show that suppression of PP2A Aβ expression permits immortalized human cells to achieve a tumorigenic state. Cancer-associated Aβ mutants fail to reverse tumorigenic phenotype induced by PP2A Aβ suppression, indicating that these mutants function as null alleles. Wild-type PP2A Aβ but not cancer-derived Aβ mutants form a complex with the small GTPase RalA. PP2A Aβ-containing complexes dephosphorylate RalA at Ser183 and Ser194, inactivating RalA and abolishing its transforming function. These observations identify PP2A Aβ as a tumor suppressor gene that transforms immortalized human cells by regulating the function of RalA.
rala  transformation  anoikis  anchorage_independence  PP2A 
29 days ago by Segalllab
Exploring non-linear transition pathways in social-ecological systems | Scientific Reports
In this paper, we analyze transition pathways and the potential outcomes that these may lead to via a stylized model of a system composed of interacting agents exploiting resources and, by extension, the overall ecosystem.
transformation  modeling 
4 weeks ago by zryb
love & longing, rabbit edition. - jaws_3 - 魔道祖师 - 墨香铜臭 | Módào Zǔshī - Mòxiāng Tóngxiù [Archive of Our Own]
Lan Wangji makes a (minor) miscalculation and gets turned into a rabbit. He then makes the (ridiculous!) mistake of seeking Wei Ying out for help.
fic  mdsz  untamed  weiwuxian/lanwangji  transformation  adorable 
4 weeks ago by sequat
what else is there? - mme_anxious - 魔道祖师 - 墨香铜臭 | Módào Zǔshī - Mòxiāng Tóngxiù [Archive of Our Own]
“Did you hear the terrible news? Yiling Laozu Wei Wuxian has gone beyond the pale! He has murdered Hanguang-Jun!”

This is the first thing the swan hears flying over Yiling, and it sets him to hissing. It’s the kind of sound he would never make as a human, but as a swan—a mute swan— hissing is the only form of communication available to Lan Wangji. So he hisses.

-

Jin Guangyao transforms Lan Wangji into a swan. Only an act of love will break the curse.
fic  mdsz  untamed  weiwuxian/lanwangji  au  transformation  presumed.dead 
4 weeks ago by sequat
far longer than forever - jaws_3 - 魔道祖师 - 墨香铜臭 | Módào Zǔshī - Mòxiāng Tóngxiù [Archive of Our Own]
“This, this is just one of the Yiling Patriarch’s tricks!” Su She bites out and Lan Wangji hears Wei Ying huff out another laugh from within his arms.

“Really? I’ve grown so powerful I can even create my own Lan Zhan’s? I really am rather impressive.”

Lan Wangji is turned into a swan. He doesn’t let that stop him from protecting Wei Ying.
fic  mdsz  untamed  weiwuxian/lanwangji  au  transformation 
4 weeks ago by sequat
far longer than forever - jaws_3 - 魔道祖师 - 墨香铜臭 | Módào Zǔshī - Mòxiāng Tóngxiù [Archive of Our Own]
“This, this is just one of the Yiling Patriarch’s tricks!” Su She bites out and Lan Wangji hears Wei Ying huff out another laugh from within his arms.

“Really? I’ve grown so powerful I can even create my own Lan Zhan’s? I really am rather impressive.”

Lan Wangji is turned into a swan. He doesn’t let that stop him from protecting Wei Ying.
fic  f:MDZS  slash  transformation  getting-together  'ao3  f:MXTX  s:WeiWuxian/LanWangji 
4 weeks ago by esther_a

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