"The study of synesthesia has helped shift the way scientists think about the brain. In the past, they have focused on matching different areas with specific functions; now, the entire organ is viewed as a tapestry of interwoven connections.

"The whole system is a giant network," Eagleman says. "It's no longer sufficient to think about single areas in isolation."

Like synesthesia, many neurological disorders — such as schizophrenia, autism,Alzheimer's disease, depression and epilepsy — have been linked to abnormal communication between brain regions. The hope is that as neuroscientists learn about how the connections in the synesthetic brain differ from those in normal brains, they will also gain insight into how these differences develop — and how they sometimes manifest as harmful disorders."

A new study reveals that people suffering from depression are characterized by an extreme synchronicity of brain regions that could indicate stymied, inflexible brains.

self-deprecato'brien

According to the World Health Organization, depression is the leading cause of disability and the fourth leading contributor to the global burden of disease, projected to reach second place by 2020. There is also strong evidence that it is an independent risk factor for heart disease, and several studies show that prolonged depression is associated with selective and possibly permanent damage to the hippocampus, a region of the brain critical to memory and learning.
Add the fact that 2 percent to 12 percent of depressed people eventually commit suicide, and the [supposed evolutionary] “advantages” of depression suddenly don’t look so good....
What is natural, the thinking goes, is best. If we are designed to suffer depression in response to life’s ills, there must be a good reason for it, and we should allow it to take its painful and natural course.
But unlike ordinary sadness, the natural course of depression can be devastating and lethal. And while sadness is useful, clinical depression signals a failure to adapt to stress or loss, because it impairs a person’s ability to solve the very dilemmas that triggered it.
Even if depression is “natural” and evolved from an emotional state that might once have given us some advantage, that doesn’t make it any more desirable than other maladies. Nature offers us cancer, infections and heart disease, which we happily avoid and do our best to treat. Depression is no different.

The problem is it's very hard to tell when a superhero is recklessly endangering himself versus when he's accepting the very real dangers of the job. Tony, who is the embodiment of reckless on a good day, doesn't know if Captain America is throwing himself into his work because it's his work, or because secretly he wishes he were dead.

It scares him. And the fact that it scares him also scares him. Tony is used to being a shallow jerk; he's very good at it. Caring about Steve to the point that he worries if the guy goes off his own personal radar for more than an hour is seriously fucking with him.

For the past several years, Bruce Greenwald and I have been engaged in research on an alternative theory of the Depression—and an alternative analysis of what is ailing the economy today. This explanation sees the financial crisis of the 1930s as a consequence not so much of a financial implosion but of the economy’s underlying weakness. The breakdown of the banking system didn’t culminate until 1933, long after the Depression began and long after unemployment had started to soar. By 1931 unemployment was already around 16 percent, and it reached 23 percent in 1932. Shantytown “Hoovervilles” were springing up everywhere. The underlying cause was a structural change in the real economy: the widespread decline in agricultural prices and incomes, caused by what is ordinarily a “good thing”—greater productivity.

At the beginning of the Depression, more than a fifth of all Americans worked on farms. Between 1929 and 1932, these people saw their incomes cut by somewhere between one-third and two-thirds, compounding problems that farmers had faced for years. Agriculture had been a victim of its own success. In 1900, it took a large portion of the U.S. population to produce enough food for the country as a whole. Then came a revolution in agriculture that would gain pace throughout the century—better seeds, better fertilizer, better farming practices, along with widespread mechanization. Today, 2 percent of Americans produce more food than we can consume.

What this transition meant

Florence Owens Thompson (September 1, 1903 – September 16, 1983), born Florence Leona Christie, was the subject of Dorothea Lange's photo Migrant Mother (1936), an iconic image of the Great Depression. The Library of Congress entitled the Migrant Mother image, "Destitute pea pickers in California. Mother of seven children. Age thirty-two. Nipomo, California."

The Grapes of Wrath is an American realist novel written by John Steinbeck and published in 1939. For it he won the annual National Book Award and Pulitzer Prize for novels and it was cited prominently when he won the Nobel Prize in 1962.

Set during the Great Depression, the novel focuses on the Joads, a poor family of sharecroppers driven from their Oklahoma home by drought, economic hardship, and changes in financial and agricultural industries. Due to their nearly hopeless situation, and in part because they were trapped in the Dust Bowl, the Joads set out for California. Along with thousands of other "Okies", they sought jobs, land, dignity, and a future.

The Grapes of Wrath is frequently read in American high school and college literature classes due to its historical context and enduring legacy. A celebrated Hollywood film version, starring Henry Fonda and directed by John Ford, was made in 1940.

The Great Depression began with the Wall Street Crash of October, 1929 and rapidly spread worldwide. The market crash marked the beginning of a decade of high unemployment, poverty, low profits, deflation, plunging farm incomes, and lost opportunities for economic growth and personal advancement. Although its causes are still uncertain and controversial, the net effect was a sudden and general loss of confidence in the economic future. The usual explanations include numerous factors, especially high consumer debt, ill-regulated markets that permitted overoptimistic loans by banks and investors, the lack of high-growth new industries, all interacting to create a downward economic spiral of reduced spending, falling confidence, and lowered production.

Industries that suffered the most included construction, agriculture as dust-bowl conditions persisted in the agricultural heartland, shipping, mining, and logging as well as durable goods like automobiles and appliances that could be postponed. The economy reached bottom in the winter of 1932–33; then came four years of very rapid growth until 1937, when the Recession of 1937 brought back 1934 levels of unemployment. The depression caused major political changes in America. Three years into the depression, Herbert Hoover lost the 1932 presidential election to Franklin Delano Roosevelt in a sweeping landslide. Roosevelt's economic recovery plan, the New Deal, instituted unprecedented programs for relief, recovery and reform, and brought about a major realignment of American politics.